EoSonics® Frag96 Sonicator

Fragmentation of Nucleic acids、chromatin or protein for NGS

EoSonics®FRAG96 Sonicator uses ACU™(Adaptive Cylindrical Ultrasonic) technology to process extracted nucleic acid、chromatin or protein. By adjusting acoustic parameters, it controls the fragmentation length of nucleic acids.

EoSonics® FRAG96 can process 1 to 96 samples per batch flexibly and can be compatible with different consumables such as 96-well PCR plates, cell culture plates, and 8-strip tube, which require low consumable costs for running different sample throughputs. There is no need to manually transfer samples to dedicated consumables during the process, and the whole plate transfer of samples can be performed for ease of automation. Compared to traditional enzymatic methods, physical ultrasonic shearing has the advantages of non-preferential sequence cutting and relatively narrowing fragment size distribution. Therefore, it is the preferred choice for sample fragmentation. This equipment does not require specialized consumables, which greatly lower the cost of consumables.

Product Features：

High Throughput: Processes up to 96 samples in a single batch.

Low Noise: Operates at ultra-high frequencies without vibration or noise.

High Flexibility: Supports flexible sample and consumable throughput from 1 to 96 samples.

No Plate Transfer: Allows direct processing of nucleic extracts and cell cultures without the need for plate transfer.

Non-contact: Utilizes a non-contact processing method with a fully enclosed reaction system to avoid sample contamination.

Good compatibility: Compatible with commonly used laboratory consumables without requiring specialized consumables.

Edge Effect Elimination: Ensures highly consistent fragmentation results across all positions.

Fatigue Resistant: Capable of continuous operation over long periods.

Product Application:

The instrument can be used for DNA/RNA/chromatin shearing, nucleic acid/protein extraction, cell lysis, tissue fragmentation, dissolution of mixtures, protein digestion reaction, etc.

Fragmentation Effect：

The image below demonstrates the DNA fragmentation result using commonly used PCR well plate. The fragment sizes are all stable at 150-450bp.